This paper develops a general account of special relations and special obligations, and uses it as a framework to argue for a modest form of speciesism – mitigated speciesism – based on an understanding of species co-membership as a thick concept. Mitigated speciesism steers a middle ground between anti-speciesism and crude speciesism. Unlike anti-speciesists, I maintain that species co-membership is a morally relevant special relation, which indeed grounds special obligations among the members of the same species. But unlike crude speciesists, (...) I argue that our special obligations to our fellow human beings do not warrant that we should always count their interests more than comparable interests of non-human animals. Instead, special obligations based on species co-membership are subject to three constraints. (shrink)

Extensive social choice theory is used to study the problem of measuring group fitness in a two-level biological hierarchy. Both fixed and variable group size are considered. Axioms are identified that imply that the group measure satisfies a form of consequentialism in which group fitness only depends on the viabilities and fecundities of the individuals at the lower level in the hierarchy. This kind of consequentialism can take account of the group fitness advantages of germ-soma specialization, which is not possible (...) with an alternative social choice framework proposed by Okasha, but which is an essential feature of the index of group fitness for a multicellular organism introduced by Michod, Viossat, Solari, Hurand, and Nedelcu to analyze the unicellular-multicellular evolutionary transition. The new framework is also used to analyze the fitness decoupling between levels that takes place during an evolutionary transition. (shrink)

Class line is a fundamental line of the Party. To be the Communist Party is to make revolution, eradicate the bourgeoisie and promote the proletariat, stress class status, and implement the proletarian class line!

This article illustrates how axiomatic social choice theory can be used in the evaluation of measures of group fitness for a biological hierarchy, thereby contributing to the dialogue between the philosophy of biology and social choice theory. It provides an axiomatic characterization of the ordering underlying the MichodSolariNedelcu index of group fitness for a multicellular organism. The MVSHN index has been used to analyse the germ-soma specialization and the fitness decoupling between the cell and organism levels that takes place during (...) the evolutionary transition to multicellularity. It is argued that some of the axioms satisfied by the MVSHN group fitness ordering are not appropriate for all stages in this transition. (shrink)

A total of 1918 loci, detected by the hybridization of 938 expressed sequence tag unigenes from 26 Triticeae cDNA libraries, were mapped to wheat homoeologous group 4 chromosomes using a set of deletion, ditelosomic, and nulli-tetrasomic lines. The 1918 EST loci were not distributed uniformly among the three group 4 chromosomes; 41, 28, and 31% mapped to chromosomes 4A, 4B, and 4D, respectively. This pattern is in contrast to the cumulative results of EST mapping in all homoeologous groups, as reported (...) elsewhere, that found the highest proportion of loci mapped to the B genome. Sixty-five percent of these 1918 loci mapped to the long arms of homoeologous group 4 chromosomes, while 35% mapped to the short arms. The distal regions of chromosome arms showed higher numbers of loci than the proximal regions, with the exception of 4DL. This study confirmed the complex structure of chromosome 4A that contains two reciprocal translocations and two inversions, previously identified. An additional inversion in the centromeric region of 4A was revealed. A consensus map for homoeologous group 4 was developed from 119 ESTs unique to group 4. Forty-nine percent of these ESTs were found to be homoologous to sequences on rice chromosome 3, 12% had matches with sequences on other rice chromosomes, and 39% had no matches with rice sequences at all. Limited homology was found between wheat ESTs on homoeologous group 4 and the Arabidopsis genome. Forty-two percent of the homoeologous group 4 ESTs could be classified into functional categories on the basis of blastX searches against all protein databases. (shrink)

The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chromosome bin map of wheat homoeologous group 2 chromosomes to determine the distribution of ESTs, construct a consensus map of group 2 ESTs, investigate synteny, examine patterns of duplication, and assess the colinearity with rice (...) of ESTs assigned to the group 2 consensus bin map. A total of 2600 loci generated from 1110 ESTs were mapped to group 2 chromosomes by Southern hybridization onto wheat aneuploid chromosome and deletion stocks. A consensus map was constructed of 552 ESTs mapping to more than one group 2 chromosome. Regions of high gene density in distal bins and low gene density in proximal bins were found. Two interstitial gene-rich islands flanked by relatively gene-poor regions on both the short and long arms and having good synteny with rice were discovered. The map locations of two ESTs indicated the possible presence of a small pericentric inversion on chromosome 2B. Wheat chromosome group 2 was shown to share syntenous blocks with rice chromosomes 4 and 7. (shrink)

Psychologists and neuroscientists extensively rely on computational models for studying and analyzing the human mind. Traditionally, such computational models have been hand-designed by expert researchers. Two prominent examples are cognitive architectures and Bayesian models of cognition. While the former requires the specification of a fixed set of computational structures and a definition of how these structures interact with each other, the latter necessitates the commitment to a particular prior and a likelihood function which – in combination with Bayes’ rule – (...) determine the model's behavior. In recent years, a new framework has established itself as a promising tool for building models of human cognition: the framework of meta-learning. In contrast to the previously mentioned model classes, meta-learned models acquire their inductive biases from experience, i.e., by repeatedly interacting with an environment. However, a coherent research program around meta-learned models of cognition is still missing to this day. The purpose of this article is to synthesize previous work in this field and establish such a research program. We accomplish this by pointing out that meta-learning can be used to construct Bayes-optimal learning algorithms, allowing us to draw strong connections to the rational analysis of cognition. We then discuss several advantages of the meta-learning framework over traditional methods and reexamine prior work in the context of these new insights. (shrink)

This report describes the rationale, approaches, organization, and resource development leading to a large-scale deletion bin map of the hexaploid wheat genome. Accompanying reports in this issue detail results from chromosome bin-mapping of expressed sequence tags representing genes onto the seven homoeologous chromosome groups and a global analysis of the entire mapped wheat EST data set. Among the resources developed were the first extensive public wheat EST collection. Described are protocols for sequencing, sequence processing, EST nomenclature, and the assembly of (...) ESTs into contigs. These contigs plus singletons were used for selection of distinct sequence motif unigenes. Selected ESTs were rearrayed, validated by 5′ and 3′ sequencing, and amplified for probing a series of wheat aneuploid and deletion stocks. Images and data for all Southern hybridizations were deposited in databases and were used by the coordinators for each of the seven homoeologous chromosome groups to validate the mapping results. Results from this project have established the foundation for future developments in wheat genomics. (shrink)

Aristotle's treatment of the choice between the political and contemplative lives (in EN I 5 and X 7-8) can seem awkward. To offer one explanation of this, I argue that when he invokes self-sufficience (autarkeia) as a criterion for this choice, he appeals to two different and incompatible specifications of "lacking nothing." On one specification, suitable to a human being living as a political animal and thus seeking to realize his end as an engaged citizen of a polis, a person (...) lacks nothing by possessing a wide range of goods that directly require other people. On the other, more suitable to a god or a beast, a person lacks nothing by having no need of goods that directly require other people. The ambiguity of this criterion renders the choice between the political and contemplative lives difficult. (shrink)

Despite the bad press, Plato has a valid argument for immortality from three premises: (1) if the natural evil of a thing cannot destroy it, then it is indestructible; (2) the natural evil of the soul is vice; and (3) vice cannot destroy the soul. These premises are contestable, of course, but Plato has some good reasons for advancing them.

This chapter presents a series of experiments that elicit causal judgments using statements that do not include the verb "to cause". In particular, our interest is in exploring the extent to which previously observed effects of normative considerations on agreement with what we call "cause"-statements, i.e. those of the form "X caused ..." extend as well to those of the form "X V-ed Y", where V is a lexical causative. Our principal finding is that in many cases the effects do (...) not extend in this way, and moreover that the cases where we do find the same pattern are those where the causal verb used has a negative valence of its own. We draw two main conclusions from this finding. First, it reveals how the almost exclusive focus on "cause"-statements in the experimental study of causal judgment has led to findings that are unrepresentative of the full range of ordinary causal thinking, and provides a proof of concept as to how this thinking can be studied in its full variety. Second, the results of our experiments provide significant indirect support for the contention that the effect of moral considerations on agreement with "cause"-statements reflect the fact that these statements are most often used to assign responsibility for an event, and not just to describe the causal structure of what happened. It is not causal judgments in general that result from a process in which normative considerations play a role, but perhaps only those judgments that express a determination of moral responsibility. (shrink)

Photo by Tingey Injury Law Firm on Unsplash ABSTRACT The coverage of healthcare costs allegedly brought about by people’s own earlier health-adverse behaviors is certainly a matter of justice. However, this raises the following questions: justice for whom? Is it right to take people’s past behaviors into account in determining their access to healthcare? If so, how do we go about taking those behaviors into account? These bioethical questions become even more complex when we consider them in the context of (...) a commitment to publicly funded, universal healthcare coverage. INTRODUCTION Healthcare coverage of lifestyle-related conditions is certainly a matter of justice. However, this raises the following justice-related question: Is it right to consider people’s past behaviors in determining their access to healthcare? If so, the methods of taking those behaviors into account must be fair and justifiable. This bioethical question becomes even more complex when we consider it in the context of a commitment to publicly funded, universal healthcare coverage. This paper takes an old, classic debate, evaluates newer approaches, and offers an argument favoring a combined approach which alters the liberal-egalitarian solution to account for social justice. ANALYSIS I. Causes of Disease If healthcare coverage were universal, irrespective of socioeconomic status and lifestyle, people would contribute to the cost of remedying the lifestyle-induced health problems of others. In the West, lifestyle-related diseases are burdensome.[i] This paper approaches this concern from a western lens that incorporates both a European tradition of “social safety nets” and an American tradition of personal freedoms. By taking such an approach, solutions to the consequences of one’s past behavior burdening others must consider an individual’s personal freedom to choose to act as he or she wishes, with the distributive social and economic equality of the many. The concept of disease caused by lifestyle and diet is proven. Many health conditions include behavioral risk factors. Multi-pack smoking increases the risk of chronic lung disease, while obesity increases the risk of type 2 diabetes. Inattention to high blood pressure, high cholesterol, and a lack of exercise leads to increased risks of coronary artery disease.[ii] While poor lifestyle choices certainly influence these conditions, their causes are multifactorial, and it is difficult to say that any single string of poor choices led to their development. In a scenario where two men excessively eat fast food for 20 years, several discrete factors impact whether any of them might suffer an ischemic-embolic stroke or not. Genetics, circumstances, and activity will also contribute to outcomes. II. Alcohol-Related End-Stage Liver Disease One paper suggests that alcohol-related end-stage liver disease (ARESLD) differs from other multifactorial disorders as alcohol alone causes the disease.[iii] It justifies attributing personal responsibility to patients with ARESLD because the condition develops only after the cumulative effects of large quantities of alcohol consumed from years to decades.[iv] However, the paper undermines its position by admitting that even the susceptibility to becoming an alcoholic has some degree of genetic predisposition.[v] Given the extreme scarcity of donor livers, some patients may be prioritized over others on the transplant waiting list. Since donor livers cannot be given to everyone, transplanting a liver into an alcoholic may result in death for competing candidates whose liver disease was not their fault. All else being equal, if bioethicists avoid claiming moral deficiency or judgment, those with apparently self-inflicted ARESLD will not be deprived of treatment but will have a lower priority for transplant.[vi] In contrast, another position suggests that it is often difficult to define what behaviors are punishable as these are largely personal and value-laden.[vii] Still, people do not support using their own resources to support the consequences of others’ poor choices, no matter how objective.[viii] In democratic societies, one must take into consideration community morals and values.[ix] Even if we were to punish people for their health-adverse behaviors, we could not logistically employ the vigorous and sustained efforts necessary to determine whose actions are morally weak.[x] III. The Liberal-Egalitarian Proposal One past argument proposes a liberal-egalitarian solution to manage personal responsibility for so-called “lifestyle diseases.”[xi] This Rawlsian system combines the European-style “social safety net” commitment to social and economic equality with the American liberal notion of pluralist toleration and personal freedoms. This idealized system aims to hold people responsible for their choices rather than the consequences to mitigate the downside of blaming those who might not be blameworthy. The approach avoids determining the questionable nature of luck and personal responsibility for health outcomes, fairness in the distribution of economic burden, and the intrusiveness required to practically determine who acts in a morally wrong and health-adverse way. The liberal-egalitarian model, a theory of distributive justice, has two facets: the liberal principle that people should be held accountable for their choices and the egalitarian principle that people who make the same choices should have the same outcomes.[xii] This model attempts to fuse responsibility with equity by seeking to reward good behavior and tax bad behavior rather than punish the consequences of the action and navigate who deserves treatment. For instance, the hospital bedside is not the appropriate place to introduce responsibility for one’s health outcomes.[xiii] This appeals to the reality that, at that time, discerning the true causes of disease was not plausible and to humanity in avoiding a heartless and cruel approach. An argument in favor of the liberal-egalitarian model considers its method of implementation. This approach assumes that the healthcare system treats all individuals regardless of their choices or ability to cover costs. The liberal-egalitarian model also assumes that a certain adverse health condition is related, statistically speaking, to the consumption of a certain good and that good can be taxed. As such, it proposes to tax the consumption of that good to finance the collective burden which arises from that good’s consumption rather than require individuals to pay for their own treatment. In the example of ARESLD, the recommended solution would be taxing all alcohol. While a systematic infrastructure is not explicit, there is the implication that a per-unit tax can be imposed on alcohol so the total tax revenue would make up for the additional healthcare costs due to consumption.[xiv] Upholding the principle that all people who make the same choices should face the same costs, all consumers of alcohol would pay the same tax, regardless of factors such as genetic predisposition to alcoholism, lifestyle, or expected cost of treatment. Upholding the principle of individual responsibility, this model does not deny treatment to anyone, neutralizing factors outside that individual’s control by imposing the tax ex-ante. Other people are not burdened by those who consume the good. People who consume alcohol face a burden proportional to the amount consumed. This tax-based implementation is justified so long as the tax is not prohibitively high for the average consumer. Further, the model mitigates concerns over the intrusiveness of ascribing morality to health-adverse behaviors. IV. Moral and Social Arguments Against the Liberal-Egalitarian Position Arguments against the liberal-egalitarian model concerns its many assumptions. First, this model assumes that consumption of such goods is directly related to the health outcome and that these goods can be taxed.[xv] Certain people genetically predisposed to alcoholism would be predisposed to consume more alcohol. The model falls short when applied to scenarios where health outcomes are not consumption-based, such as engaging in unsafe sex or abstaining from healthy lifestyle choices like exercise. Second, some might argue that the liberal-egalitarian model fails to remain neutral. Residual moral judgments tied to consumption choices introduce non-neutrality. Although taxation in free societies is determined by democratic procedures rather than by individuals in the healthcare system, moral and value-based judgments will be implicit in deciding what behaviors are taxable, such as the purchase of cigarettes. Third, the liberal-egalitarian model fails to determine whether one’s behavior is autonomous, as socio-cultural-economic factors may influence it and behavior is more a product of society, peer pressure, or income. Those also may reflect systemic inequalities. Therefore, this model, which rewards, or taxes based solely on decisions, regardless of their consequences and motivations, fails to consider that a person’s decisions may not be completely autonomous. V. Libertarian Arguments Against the Liberal-Egalitarian Model a. State Intrusiveness as Counter to the Liberal-Egalitarian Model Last, there is a libertarian worry that if the state guarantees universal healthcare coverage to all people, the state will have to become highly intrusive and investigate people’s morals.[xvi] At least one-third of all disease burden in North America, Europe, and the Asia-Pacific is attributable to lifestyle measures such as tobacco smoking, alcohol consumption, high cholesterol, and obesity.[xvii] With these various lifestyles, it is not likely to agree on what conduct to tax or condemn.[xviii] The fine-toothed comb required to determine whether each citizen has been engaging in these behaviors would intrude on daily life and personal freedom. Libertarians champion the argument that impractical intrusiveness would result from universal healthcare, and such a degree of intrusiveness would likely be universally unacceptable.[xix] The liberal-egalitarian model mitigates the libertarian worry about state intrusiveness as it does not involve prying into one’s life and choices other than taxing goods. A liberal state should ideally be neutral to how people decide to live their lives. In all, libertarians can rest assured that the liberal-egalitarian tax-based model, through its ex-ante implementation, will require no prying state eyes. States that provide universal healthcare coverage and wish to condemn certain misconduct do not need to become overly intrusive to carry out measures to hold individuals accountable. b. Fairness Another libertarian worry regarding the guarantee of universal healthcare coverage in the context of lifestyle-driven diseases is that the public will be burdened unfairly with covering others’ ill-advised mistakes or bad luck. An ideal system to address this worry would link treatment or payment for treatment with whatever behavior caused that need.[xx] The distribution of burdens should be linked to how different individuals contributed to the creation of those burdens. Applied to health policy, we should ask how the need for a certain treatment arose when determining how to distribute its cost.[xxi] The liberal-egalitarian model aspires to hold individuals responsible for their choices, not for the consequences of such choices. This model significantly mitigates the libertarian worry over unfair burdens for covering other people’s mistakes or social conditions, which lead to those bad outcomes, by ensuring to not burden others with any of the costs for the treatment of people who decide to engage in certain health-adverse behaviors. The aforementioned taxation-based system would only tax those who also engage in the health-adverse behavior through consumption, and that tax directly pays for the necessary collective treatment. As such, those who do not consume the good are not involved with the payment scheme, while those who do consume the good are responsible for payment in a matter proportional to the amount of the good they have consumed. VI. Universal Coverage Taking a step back, one should consider whether these worries regarding the coverage of apparently self-inflicted health conditions in the context of universal healthcare are worthwhile issues. One perspective raises what is called the culturally imagined objection — an idea erroneously held by many that sick people, especially those who are poor and uneducated, bring these illnesses upon themselves due to poor decision-making and irresponsible risk-taking.[xxii] This perspective critiques the uniquely American view that, since individuals are free to choose their lifestyles, they should bear the costs of their lifestyle.[xxiii] Taking this argument further, some (perhaps the strongly libertarian) would say that the poor health status among many individuals is the price individuals must pay for their American way of life and the liberty and freedom to live as they wish. However, people should not completely punish individuals for their health-adverse behaviors because these choices are largely pre-determined by a person’s socioeconomic influences.[xxiv] The outcomes from these allegedly ill-advised behaviors, which largely affect poorer people, are not just poor behavior but rather a public health crisis. Perhaps the state and its people should take collective responsibility and cover the costs of treatment for those health outcomes without question, as a form of public service. Rather than worrying about accountability and taxing bad behavior or intrusiveness into personal decisions, some might argue that people need to collectively take responsibility for reducing the overarching systemic inequalities and covering the associated treatment costs as a measure of public health. VII. Proposed Solution Given the strengths of the liberal-egalitarian model and taking into account libertarian and social justice-oriented objections, an ideal solution for the coverage of lifestyle-related health problems needs to consider the complex relationship between a person’s behaviors and their apparent health outcomes. It must consider how society as a whole passes judgment on behaviors and how to take into account that many health-adverse decisions are not truly autonomous decisions, as various genetic and socioeconomic factors influence them. An ideal solution combines the liberal-egalitarian tax-based model with the social justice concerns of universal coverage. Whatever the cost for the treatment of medical issues resulting in part or entirely from lifestyle and diet, taxes collected from spending associated with the behavior (like the purchase of alcohol, junk food, and cigarettes) ex-ante should fund 50 percent of the cost of treatment, while the universal healthcare taxation scheme should include the other 50 percent. Such a system would provide an incentive to avoid the purchases that can lead to unhealthy consumption and make healthier choices, slightly punish and discourage such purchases through taxation, yet not overly punish people whose outcomes may have more to do with socioeconomic factors and genetics. Adding public responsibility demonstrates acknowledgement that health care is in the public interest and can mitigate public health inequalities. This solution would fuse personal responsibility with the public responsibility of state-sponsored social improvement while ensuring that all people have fair access to necessary treatment, no matter their ability to pay. CONCLUSION The 50-50 system this paper proposes reflects both justice and personal responsibility in covering healthcare costs allegedly brought about by people’s own health-adverse behaviors. By allocating tax revenue from consumption that contributes or even alone causes poor health outcomes, such a system incorporates personal responsibility. By using general tax revenue for health care, such a system would meet the libertarian requirement of providing care without any moral investigation of past behaviors and the social justice consideration of providing health care to those who may have unwittingly ventured into ill-health due to systemic injustice, socioeconomics, or genetics. - [i] Cappelen, A. W. (2005). Responsibility in health care: A liberal egalitarian approach. Journal of Medical Ethics, 31(8), 476–480. https://doi.org/10.1136/jme.2004.010421 [ii] Moss, A. H. (1991). Should alcoholics compete equally for liver transplantation? JAMA: The Journal of the American Medical Association, 265(10), 1295–1298. https://doi.org/10.1001/jama.1991.03460100097032 [iii] Moss, p. 1295-1298. [iv] Moss, p. 1296. [v] Moss, p. 1295-1298. [vi] Moss, p. 1295-1298. [vii] Cohen, C. IS THIS SUPPOSED TO BE COHEN AND BENJAMIN (1991). Alcoholics and liver transplantation. JAMA: The Journal of the American Medical Association, 265(10), 1299–1301. https://doi.org/10.1001/jama.1991.03460100101033 [viii] Cohen, p. 1299-1301. [ix] Moss, p. 1297. [x] Cohen, p. 1300. [xi] Cappelen, p. 478-480. [xii] Cappalen, p. 478-480. [xiii] Cappelen, p.479. [xiv] Cappelen, p. 479. [xv] Cappelen, p. 479 [xvi] Cohen, p. 1301. [xvii] Cappelen, p. 478. [xviii] Cohen, p. 1299-1301. [xix] Cohen, p. 1301. [xx] Cappelen, p. 476-480. [xxi] Cappelen, p. 476-480. [xxii] Kawachi, I. (2005). Why the United States is not number one in Health. Healthy, Wealthy, and Fair, 18–33. https://doi.org/10.1093/acprof:oso/9780195170665.003.0013 [xxiii] Kawachi, p. 18-33. [xxiv] Kawachi, p. 18-33. (shrink)

Leah Kalmanson's Cross-Cultural Existentialism offers an original and provocative interpretation of existentialist themes and threads running through classical and modern East Asian Buddhist and Ruist philosophical sources. The book takes its point of departure in existential questions concerning meaningfulness and meaning-formative practices, as articulated in European existentialism and postexistentialism, and traces how these questions are and can be addressed in their own terms in dharmic and Song dynasty Ruist discourses of karma, vital force, and ritual propriety. The book elucidates existential (...) techniques and practices encompassing case studies of Buddhist... (shrink)

Some realists claim that theoretical entities like numbers and electrons are indispensable for describing the empirical world. Motivated by the meta-ontology of Quine, I take this claim to imply that, for some first-order theory T and formula δ(x) such that T ⊢ ∃xδ ∧ ∃x¬δ, where δ(x) is intended to apply to all and only empirical entities, there is no first-order theory T′ such that (a) T and T′ describe the δ:s in the same way, (b) T′ ⊢ ∀xδ, and (...) (c) T′ is at least as attractive as T in terms of other theoretical virtues. In an attempt to refute the realist claim, I try to solve the general problem of nominalizing T (with respect to δ), namely to find a theory T′ satisfying conditions (a)–(c) under various precisifications thereof. In particular, I note that condition (a) can be understood either in terms of syntactic or semantic equivalence, where the latter is strictly stronger than the former. The results are somewhat mixed. On the positive side, even under the stronger precisification of (a), I establish that (1) if the vocabulary of T is finite, a nominalizing theory can always be found that is recursive if T is, and (2) if T postulates infinitely many δ:s, a nominalizing theory can always be found that is no more computationally complex than T. On the negative side, even under the weaker precisification of (a), I establish that (3) certain finite theories cannot be nominalized by a finite theory. (shrink)

It has become increasingly evident that gene content of the sex chromosomes is markedly different from that of the autosomes. Both sex chromosomes appear enriched for genes related to sexual differentiation and reproduction; but curiously, the human X chromosome also seems to bear a preponderance of genes linked to brain and muscle functions. In this review, we will synthesize several evolutionary theories that may account for this nonrandom assortment of genes on the sex chromosomes, including 1) asexual degeneration, 2) sexual (...) antagonism, 3) constant selection, and 4) hemizygous exposure. Additionally, we will speculate on how the evolution of sex‐chromosome gene content might have impacted on the phenotypic evolution of mammals and particularly humans. Our discussion will focus on the mammalian sex chromosomes, but will cross reference other species where appropriate. BioEssays 26:159–169, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Let X be an infinite set and let and denote the propositions “every filter on X can be extended to an ultrafilter” and “X has a free ultrafilter”, respectively. We denote by the Stone space of the Boolean algebra of all subsets of X. We show: For every well‐ordered cardinal number ℵ, (ℵ) iff (2ℵ). iff “ is a continuous image of ” iff “ has a free open ultrafilter ” iff “every countably infinite subset of has a limit point”. (...) implies “every open filter on extends to an open ultrafilter” implies “has an open ultrafilter” implies It is relatively consistent with that (ω) holds, whereas (ω) fails. In particular, none of the statements given in (2) implies (ω). (shrink)

This essay contrasts two approaches to permissible self-defensive killing. The first is the forfeiture approach; the second is the elbow room for self-defense approach. The forfeiture approach comes in many versions — not all of which make prominent use of the word “forfeiture.” However, all versions presume that the permissibility of X killing Y (when X must kill Y in order to prevent herself from being unjustly killed) depends entirely on there being some feature of Y in virtue of which (...) Y has become liable to be killed, that is, in virtue of which Y has forfeited or lost or been stripped of his right not to be killed. Different versions of the forfeiture approach advance different claims about what feature of Y will render Y liable to being killed by X. I criticize versions of this approach offered by Thomson, Otsuka, and McMahan and argue that the shared deep error is the presumption that the permissibility of X’s action turns entirely on some feature of Y. In focusing entirely on Y, the forfeiture approach fails to take seriously X’s right of self-defense. In contrast, the elbow room for self-defense approach starts with an explication of a plausible right of self-defense and maintains that a proper explication of Y’s right not to be killed must make moral elbow room from X’s exercise of this right. Within the elbow room approach, Y’s liability to being killed is based upon X’s right of self-defense rather than the permissibility of X’s killing Y being based upon Y’s forfeiture. (shrink)

To meet the stability requirements for moving quadruped robots, it is important to design a rational structure for a single leg and plan the trajectory of the foot. First, a novel electrically driven leg mechanism for a quadruped robot is designed in this paper to reduce the inertia of the leg swing. Second, a modified foot trajectory based on a compound cycloid is proposed, which has swing-back and retraction motion and continuous velocity in the x-axis direction. Third, a Simulink platform (...) is built to verify the correctness of the proposed foot trajectory. The simulation result shows that when the flight phase and the stand phase switch, the impact of torque is smaller than the foot trajectory before modification. Finally, an experimental platform is constructed, and a control algorithm is written into the controller to realize the foot proposed trajectory. The results of the experiment prove the feasibility of the leg mechanism and the rationality of the proposed foot trajectory. (shrink)

It is time that we in organization sciencesdevelop and implement a new mental model forcause and effect relationships. The dominantmodel in research dates at least to the 1700sand no longer serves the full purposes of thesocial science research problems of the21st century. Traditionally, research is``essentially concerned with two-variableproblems, linear causal trains, one cause andone effect, or with few variables at the most''(von Bertalanffy, 1968, p. 12). However, theliterature is replete with examples ofphenomena in which the traditional cause andeffect construct does (...) not allow for greaterunderstanding and insight into the phenomena. Different conceptions of cause and effectrelationships have been developed includingproducer/product relationships (Ackoff 1981),design causality (Argyris and Schon, 1996), andfour classes of causal models (Schwartz andOgilvy, 1979). Of interest here is thepossibility of mutual causality, ``theassumption that the relationship between two(or more) phenomena is heavily influenced bythe presence of feedback loops that areinstantaneous, or nearly so'' (Dent, 1999). Maturana's (1998, Maturana and Varela, 1987)work on a new epistemology and ontologyprovides a foundation for the alternative modelof cause and effect proposed here. Thisinteraction model includes the dynamics of thetraditional X and Y, but adds the structure ofX (A), the structure of Y (B), the environment(E), and time (T). (shrink)

In \(\textbf{ZF}\), the well-known Fichtenholz–Kantorovich–Hausdorff theorem concerning the existence of independent families of _X_ of size \(|{\mathcal {P}} (X)|\) is equivalent to the following portion of the equally well-known Hewitt–Marczewski–Pondiczery theorem concerning the density of product spaces: “The product \({\textbf{2}}^{{\mathcal {P}}(X)}\) has a dense subset of size |_X_|”. However, the latter statement turns out to be strictly weaker than \(\textbf{AC}\) while the full Hewitt–Marczewski–Pondiczery theorem is equivalent to \(\textbf{AC}\). We study the relative strengths in \(\textbf{ZF}\) between the statement “_X_ has (...) no independent family of size \(|{\mathcal {P}}(X)|\) ” and some of the definitions of “_X_ is finite” studied in Levy’s classic paper, observing that the former statement implies one such definition, is implied by another, and incomparable with some others. (shrink)

Mack critically surveys a range of arguments characteristic of Randian writings in ethics (including Craig Biddle's Loving Life). He focuses on "the Shuffle," a set of argumentative moves in which there is illicit shifting back and forth between causal and conceptual understandings and defenses of claims of the form: Man's survival requires man's behaving in manner X (e.g., being rational, being productive). Mack concludes that much Randian argumentation is deeply flawed and urges admirers to discriminate between Rand's genuine individualist ethical (...) crusade and her line-by-line argumentation, which includes a much too strict identification of man's good with man's survival. (shrink)

"Williams has found an ingeniously indirect method for dealing with powerful and conservative voices in Trakl criticism, a method that unburdens the debate of its weighty pomposity and elicits delight from readers familiar with the critical context."_Francis Michael Sharp, author of The Poet's Madness: A Reading of Georg Trakl 1993. x, 350 pages.

Many philosophers maintain that causation is to be explicated in terms of a kind of dependence between cause and effect. These “dependence” theories are opposed by “production” accounts which hold that there is some more fundamental causal “oomph”. A wide range of experimental research on everyday causal judgments seems to indicate that ordinary people operate primarily with a dependence-based notion of causation. For example, people tend to say that absences and double preventers are causes. We argue that the impression that (...) commonsense causal discourse is largely dependence-based is the result of focusing on a very narrow class of causal verbs. Almost all of the vignette-based experimental work on causal judgment has been prosecuted using the word “cause”. But much ordinary causal discourse involves special causal verbs, such as “burn” and “crack”. We find that these verbs display a quite different pattern from the verb “cause”. For instance, for absences and double preventers (Studies 1-3), we find that while people are inclined to say that X caused Y to burn, turn, crack or start, they are less inclined to think that X burned, turned, cracked or started Y. In Study 4, we find that for chains involving a distal and proximal event, people are inclined to say that the distal event is not a special cause of the outcome, though it is a “cause” of the outcome. Together, we find a surprising double dissociation between “cause” and a stock of special causal verbs. We conclude by suggesting that much commonsense causal judgment, which heavily trades in special causal verbs, might be better captured by production-based accounts of causation. (shrink)

In “A Short Refutation of Ethical Egoism,” Richmond Campbell purports to refute “the view that everyone ought to do what benefits him the most in a given situation.” This is the theory which is “sometimes called impersonal ethical egoism ” [249). Campbell takes the following proposition as fundamental to his refutation of IEE.I. If an agent ought to do something in a given situation and another agent ought to do something in the same situation, then it is not logically impossible (...) for them to do these things in that situation [250].Granted proposition I, Campbell's refutation would require only:II. There is a situation S where an agent M would benefit most from doing X and another agent N would benefit most from doing what would prevent M from doing X [251]. (shrink)

You are presented with a choice between two envelopes. You know one envelope contains twice as much money as the other, but you don't know which contains more. You arbitrarily choose one envelope -- call it Envelope A -- but don't open it. Call the amount of money in that envelope X. Since your choice was arbitrary, the other envelope (Envelope B) is 50% likely to be the envelope with more and 50% likely to be the envelope with less. But, (...) strangely, that very fact might make Envelope B seem attractive: Wouldn't switching to Envelope B give you a 50% chance of doubling your money and a 50% chance of halving it? Since double or nothing is a fair bet, double or half is more than fair. Applying the standard expectation formula, you might calculate the expected value of switching to Envelope B as (.50)½X [50% chance it has less] + (.50)2X [50% chance it has more] = (1.25)X. So, it seems, you ought to switch to Envelope B: Your expected return -- your return on average, over the long run, if you did this many times -- would seem to be 25% more. But obviously that's absurd: A symmetrical calculation could persuade you to switch back to Envelope A. Hence the paradox. (shrink)

This chapter [of the edited volume, A Companion to Ancient Philosophy] examines the shift in Plato’s account of the eidē or ‘forms’ from the Republic to the Parmenides. Forms in the Republic are characterized in terms of perfection, purity, and changelessness, with the form being an ultimate explanatory principle for being-X. Participants, while being-X, are also capable of not-being-X, either through qualitative change and coming-to-be, or through external changes in perspective or opinion, by which they “appear [φανήσεται]” not-X (R. V.479a7). (...) The form is treated as prior to participant and as prior to mixture with what would deny what it is. It is intrinsically changeless and not subject to changes in appearance. -/- In the Parmenides, the account of form shifts to accommodate the types of admixture demanded for combination with and division from other forms. In the Fifth Hypothesis, forms are subject to determinate “bonds of being and not-being,” which permits the form to present itself as an object of discursive knowing, being-X, -Y, and -Z, and not-being not-X, not-Y, and not-Z. Forms are still treated as pure and perfect, but now with the power of gathering together intelligible bonds of being and not-being. Thus, in the Parmenides, forms are the gathering source and the gathered terms subject to the admixture; they are that by which true speech is explained. In this chapter, I argue that the “turning of the soul from becoming to truth and being” (R. VII.525c) announced in the Republic is partially fulfilled through the account of veridical speech in the Parmenides. (shrink)

This experiment investigated the effect of format (line vs. bar), viewers’ familiarity with variables, and viewers’ graphicacy (graphical literacy) skills on the comprehension of multivariate (three variable) data presented in graphs. Fifty-five undergraduates provided written descriptions of data for a set of 14 line or bar graphs, half of which depicted variables familiar to the population and half of which depicted variables unfamiliar to the population. Participants then took a test of graphicacy skills. As predicted, the format influenced viewers’ interpretations (...) of data. Specifically, viewers were more likely to describe x–y interactions when viewing line graphs than when viewing bar graphs, and they were more likely to describe main effects and “z–y” (the variable in the legend) interactions when viewing bar graphs than when viewing line graphs. Familiarity of data presented and individuals’ graphicacy skills interacted with the influence of graph format. Specifically, viewers were most likely to generate inferences only when they had high graphicacy skills, the data were familiar and thus the information inferred was expected, and the format supported those inferences. Implications for multivariate data display are discussed. (shrink)

In the context of computational social choice, we study voting methods that assign a set of winners to each profile of voter preferences. A voting method satisfies the property of positive involvement (PI) if for any election in which a candidate x would be among the winners, adding another voter to the election who ranks x first does not cause x to lose. Surprisingly, a number of standard voting methods violate this natural property. In this paper, we investigate different ways (...) of measuring the extent to which a voting method violates PI, using computer simulations. We consider the probability (under different probability models for preferences) of PI violations in randomly drawn profiles vs. profile-coalition pairs (involving coalitions of different sizes). We argue that in order to choose between a voting method that satisfies PI and one that does not, we should consider the probability of PI violation conditional on the voting methods choosing different winners. We should also relativize the probability of PI violation to what we call voter potency, the probability that a voter causes a candidate to lose. Although absolute frequencies of PI violations may be low, after this conditioning and relativization, we see that under certain voting methods that violate PI, much of a voter's potency is turned against them - in particular, against their desire to see their favorite candidate elected. (shrink)

The “culture wars” include debates about the “social construction” of X, where X includes, but is not limited to, quarks, the child viewer of television, and Zulu nationalism. Ian Hacking, with his usual erudition and style, analyzes the nature of “social construction” and uncovers the political and philosophical issues that drive these debates. Unlike most of the books associated with these “wars,” Hacking's book is not polemical, but rather attempts to understand the nature of the conflict without taking up sides.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Daemonic Figures: Shakespeare and the Question of ConscienceEric SpencerDaemonic Figures: Shakespeare and the Question of Conscience, by Ned Lukacher; x & 228 pp. Ithaca: Cornell University Press, 1994, $37.50 cloth, $15.95 paper.Daemonic Figures is a specialist’s book twice over. Profiting from it requires not only considerable familiarity with Heidegger, but also unquestioning acceptance of the rhetorical conventions and critical methods of contemporary theory. Lukacher uses these conventions and (...) methods to argue that conscience, properly understood, poses uncomfortable questions about the origins of self-knowledge, and leads to a mysterious but presumably enriching encounter with the limits of our certainty. Shakespeare enters the argument as the supreme example of a poet who discovers, through sensitivity to the ambiguities of language, how to peer without flinching into the Heideggerian abyss. Although the book relies too heavily on Heidegger’s unforgiving idiom, and pauses too seldom to justify suggestive but tenuous claims, at its heart lie hard, interesting questions about what having a conscience means.Lukacher wishes to restore to the idea of conscience all its paradoxical force. As a silent inner voice carrying a moral imperative from elsewhere, conscience immediately suggests an internally divided self. And although, according to Lukacher, Christian tradition locates the source of the imperative in God, and classical tradition in natural law, conscience remains irreducibly “uncanny,” because “the most intimate site of human habitation [i.e., the self] is also the strangest of places, for it is there that the (unfamiliar) god comes to presence through the language of moral judgment that tells us that we are and that because we are what we are we should act thus” (p. 7). For Lukacher, then, the question of conscience is the question of being, a question without an answer because it involves the unthinkable idea of something prior to and beyond being. The book argues that whatever speaks to us under the name of conscience must be both within and without any categories we have to explain it.Hence “daemonic figures”: drawing on the Greek notion of a realm of daimones dwelling between the human and divine worlds, Lukacher claims that the “daemon is the cipher, the name, and the figure for the incontrovertible [End Page 240] ghostliness, the familiar strangeness, that dwells between the perceptions and reflections of consciousness and the enigmatic ground of Being itself” (p. 2), or “the medium in which we come to ourselves as precisely that which is divided from itself... from the outset” (p. 6). And because, in Lukacher’s scheme, language articulates this daemonic mediation, we must seek in literary works which explore conscience—like Hamlet and Macbeth—traces of uncanniness welling up through ostensibly coherent words. Literary value accordingly involves “giving us the words with which to bring that enigmatic lack to presence” (p. 92). Simultaneously ubiquitous and inscrutable, conscience both calls to and evades us, and literature makes its home in such paradoxical territory.It follows that Lukacher seeks in texts brief flashes of something else in the midst of what’s apparently going on, a procedure which constantly risks arbitrary idiosyncrasy. For instance, in his chapter on Hamlet, Lukacher notes that the Player’s description of Priam’s death includes a line—“and with a hideous crash / Takes prisoner Pyrrhus’ ear”—whose sequence of sounds produces a ghostly authorial signature: sh... akes... Pyr... ear. And because this “countersignature” appears fragmented, in a context of hesitation, destruction and decline, Lukacher claims it creates an allegory of the “nonrelation at the heart of self-revelation” (p. 135). That is, it (and the larger drama of Hamlet’s revenge to which it obliquely gestures) reveals that at the heart of authorship, of authorized speech, of the moral law of conscience, lies “the silent play of the letter” (p. 135), the “daemonic figure” of dissolution in the midst of self-assertion, which unsettles all authorization. Hence Hamlet’s famous difficulties—he hears the whisper of Otherness in what ought to be a straightforward moral imperative to vengeance.Lukacher justifies this procedure by noting that “Derrida’s writing, no less than that of Heidegger [and presumably Shakespeare], relies on the invention of figures and metaphors through which... (shrink)

In quantum field theory, coherent states can be created that have negative energy density, meaning it is below that of empty space, the free quantum vacuum. If no restrictions existed regarding the concentration and permanence of negative energy regions, it might, for example, be possible to produce exotic phenomena such as Lorentzian traversable wormholes, warp drives, time machines, violations of the second law of thermodynamics, and naked singularities. Quantum Inequalities have been proposed that restrict the size and duration of the (...) regions of negative quantum vacuum energy that can be accessed by observers. However, QIs generally are derived for situations in cosmology and are very difficult to test. Direct measurement of vacuum energy is difficult and to date no QI has been tested experimentally. We test a proposed QI for squeezed light by a meta-analysis of published data obtained from experiments with optical parametric amplifiers and balanced homodyne detection. Over the last three decades, researchers in quantum optics have been trying to maximize the squeezing of the quantum vacuum and have succeeded in reducing the variance in the quantum vacuum fluctuations to \ dB. To apply the QI, a time sampling function is required. In our meta-analysis different time sampling functions for the QI were examined, but in all physically reasonable cases the QI is violated by much or all of the measured data. This brings into question the basis for QI. Possible explanations are given for this surprising result. (shrink)

DNA repetitions may provoke heterochromatinization. We explore here a model in which multiple cis‐acting sequences that display no silencing activity on their own (protosilencers) may cooperate to establish and maintain a heterochromatin domain efficiently. Protosilencers, first defined in budding yeast, have now been found in a wide range of genomes where they appear to stabilize and to extend the propagation of heterochromatin domains. Strikingly, isolated or moderately repeated protosilencers can also be found in promoters where they participate in transcriptional activation (...) and have insulation functions. This suggests that the proper juxtaposition of a threshold number of protosilencers converts them from neutral or transactivating elements into ones that nucleate heterochromatin. Interactions might be transient or permanent, and are likely to occur over distances by looping. This model provides a conceptual framework for as varied phenomena as telomere‐driven silencing in Drosophila, X inactivation in mammals, and rDNA silencing in S. cerevisiae. It may also account for the silencing that occurs when multiple copies of a transgene are inserted in tandem. BioEssays 24:828–835, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

Altered attachment characteristics may disturb the HPA and can even cause changes in the hippocampus. However, it is unknown if that will influence spatial navigation performance, learning and recalling. In this study we pretend to verify if there are differences in spatial navigation learning and was associated with attachment style dimensions of anxiety and close-depend. Sixty-five female participants were recruited and were evaluated using the Adult Attachment Scale-R and tested on a virtual maze navigation task (VMT) at one moment (exploratory (...) trial + 3 trials) and 24h later (3 trials). There was a significant Moment x Trial x Close-Depend interaction for the outcome time, F (2, 126) = 3.807, p = 0.025, with post-hoc analysis indicating that the High Close-Depend group displayed significant improvements between Trial 1 and Trial 3 in the post-test assessment. Conversely, the Low Close-Depend group displayed significant improvements between Trial 1and Trial 3 but on the pre-test assessment. Furthermore, the Low Close-Depend group presented significant better performance in pre-test Trial 3 in comparison to the High Close-Depend group. Thereby, it seems that low comfort with proximity and trust in others is associated with reduced spatial navigation recall, although spatial learning performance was actually superior in these participants. It is possible that reduced exposure to social interaction and meaning relationship may be reduced in the Low Close-Depend group, leading to modifications in hippocampal function and, ultimately, reduced spatial recall. Conversely, participants with high comfort with proximity and trust in others may not display typical spatial learning in the proposed task as they are more willing to freely explore the presented environment. (shrink)

Philosophers and ethicists have long neglected moral questions that arise from our interaction with non-human animals. Most assumed that human beings have a higher moral status than other animals, and that it is therefore morally permissible to use non-human animals as a source of food, clothing, and entertainment, and for scientific purposes. In recent decades, however, that assumption has been challenged, and the moral status of non-human animals is now the subject of a lively and controversial academic debate.Advances in sciences, (...) particularly the advent of evolutionary theory, made us realize that human beings and other animals are more similar than different, and force us to rethink our place in nature. We are no longer justified in thinking of ourselves as the crown of creation. We now understand that we are just one species among others, and we must ask ourselves anew – with an open and critical mind and without bias – which values and principles should guide our interaction with non-human animals, and how we should weigh our interests against those of other animals.Recognizing this important trend in moral thinking, the Bangladesh Journal of Bioethics invited me to edit a special issue on animal ethics. The interest was so great that one issue became two, of which this is the first. I am grateful to Professor Shamima Parvin Lasker and Ms. Tahera Ahmed for giving me the opportunity to serve as a guest editor, and for their assistance during the editing process. I also thank our contributors for choosing this journal to publish their excellent work, and the reviewers for their insightful comments and suggestions.This, the first special issue on animal ethics contains the following five articles:Robin Attfield and Rebekah Humphreys (“Justice and Non-Human Animals”) challenge the widely held belief that non-human animals are not included within the scope of the principles of justice, and suggest that the interests of non-human animals sometimes take precedence over the interests of human beings. The implications of their argument for our interaction with other animals are profound: E.g., it is a matter of justice and fairness to prevent avoidable and unnecessary animal suffering, rather than a mere matter of compassion.Eric X. Qi (“Special Relations, Special Obligations, and Speciesism”) develops an account of the moral significance of special relations, and uses it to argue for a modest form of speciesism that steers a middle ground between anti-speciesism and crude speciesism. Unlike anti-speciesists, he maintains that species co-membership grounds special moral obligations among the members of the same species. In contrast to crude speciesists, however, he holds that our special obligations to fellow human beings do not warrant that we always attach more weight to their interests than to the comparable interests of non-human animals.Yamikani Ndasaukaand Grivas M. Kayange (“Existence and Needs: A case for the equal moral considerability of non-human animals”) argue that the existentialist view that human beings have a higher moral status than other animals rests on a weak foundation. They consider a number of arguments that have been made in support of this view and conclude that none of them holds up to critical scrutiny. They then suggest that human beings and other animals in fact deserve equal moral consideration, and – drawing from Martin Heidegger and Abraham Maslow – ground that claim in two important commonalities between them.Sreetama Chakraborty (“Animal Ethics: Beyond Neutrality, Universality, and Consistency”) explains how the postmodern approach to animal ethics departs from the traditional approach, particularly its emphasis on the principles of neutrality, universality, and consistency, and draws attention to the pernicious hierarchy of domination that separates human beings from other animals. Building on the insights of postmodernism, she takes first steps towards a new, non-anthropocentric paradigm, in the hope to achieve a sustainable balance between human interests and the interests of non-human animals.Gabriel Vidal Quiñones (“Singerian Vegetarianism and the Limits of Utilitarianism: A path towards a Meaning Ethics”) takes a critical look at Peter Singer’s utilitarian argument for vegetarianism, and argues that the conceptual resources of utilitarianism only allow for an incomplete moral understanding of our relationship with other animals. What is lacking, he suggests, is an ethical vision. He argues that, without an ethical vision, human action threatens to degenerate into mere automatism without meaning. He proposes a “meaning ethics” that he thinks is better equipped to help us decide how we ought to treat other animals.I hope you, dear reader, will enjoy reading through this remarkable collection of articles as much as I enjoyed putting it together. Maybe you will even be inspired to do some thinking of your own about issues of animal ethics and put your thoughts down on paper. If so, I sincerely hope that you will choose the Bangladesh Journal of Bioethics to publish your article.Warm regards and best wishes for the new year. (shrink)